Effective 2D model does not account for geometry sensing by self-organized proteins patterns

J. Halatek, E. Frey
2014 Proceedings of the National Academy of Sciences of the United States of America  
Here we provide a thorough discussion of the model for Min protein dynamics proposed by Schweizer et al. [11]. The manuscript serves as supplementary document for our letter to the editor to appear in PNAS. Our analysis is based on the original COMSOL simulation files that were used for the publication. We show that all computational data in Schweizer et al. rely on exploitation of simulation artifacts and various unmentioned modifications of model parameters that strikingly contradict the
more » ... imental setup and experimental data. We find that the model neither accounts for MinE membrane interactions nor for any observed MinDE protein patterns. All conclusions drawn from the computational model are void. There is no evidence at all that persistent MinE membrane binding has any role in geometry sensing.
doi:10.1073/pnas.1220971111 pmid:24706883 pmcid:PMC4020076 fatcat:plyxsx6usnbg7kfad4tgzwvg3e