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Ribonucleosides are converted to deoxyribonucleosides by a biochemical process that removes the 2'-hydroxyl group, and that could have removed the 3'-hydroxyl group instead with a different enzymatic preference. This raises the question of whether there is some intrinsic chemical preference for the natural structure of DNA, with its phosphate links joining the 3' and 5' positions of adjacent bases. We have prepared DNA isomers in which we use 3'deoxynucleosides, and which have the unnaturaldoi:10.1351/pac199668112037 fatcat:4vpr4nlvh5ebznkl2hnupytfj4