Members of the genus Ranavirus, one of five genera withinthe family Iridoviridae, encompass a group of large, doublestrandedDNA viruses that infect all three classes of ectothermicvertebrates: fish, amphibians, and reptiles. Ranaviruses areglobally emerging pathogens that cause considerable morbidityand mortality among diverse populations. In North America,ranavirus epizootics are regularly reported in wild and culturedfish, amphibian, and reptile populations.