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The fetus represents a foreign entity to the maternal immune system, yet this "natural" allograft is not normally rejected. This unique situation provides a physiologic system to evaluate peripheral tolerance in which the maternal immune system is challenged with relatively rare Ags not previously encountered in the thymus. Using H-Y-specific TCR transgenic mice, we demonstrate that T cells specific for fetal Ags decrease in an Ag-specific manner during pregnancy and remain low postpartum, thedoi:10.4049/jimmunol.160.7.3086 fatcat:bjlkwunrybdmvc4jhljxoxpxrq