Objective: to develop a histochemical staining technique that allows to make a more complete evaluation of the morphological characteristics of both separate cells and tissue structures in comparison with other methods. Materials. Data from sectional examination of 70 subjects: 35 subjects of the control group (staining of ligament fragments in this group was carried out with hematoxylin-eosin) and 35 subjects of the main group (staining of ligament fragments in this group was performed with

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... uidine blue and nuclear strong red). Results. The range of values of the nuclear-cytoplasmic ratio when material was stained with toluidine blue and nuclear fast red was much narrower and contained less «emissions» than the range of values of the nuclear-cytoplasmic ratio when stained with hematoxylin-eosin: 0.46 ± 0.04 and 0.46 ± 0.07, respectively. Conclusion. The proposed new staining method makes it possible to get the preparation quickly (the time from the moment of taking the material till procurement of the finished preparation is about 3 hours), and besides, it ensures obtainment of data with a smaller spread of the values of the nuclear-cytoplasmic ratio in comparison with the traditional staining technique.