One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid

Jin Tong-Shou, Zhao Ying, Liu Li-Bin, Li Tong-Shuang
2005 E-Journal of Chemistry  
An efficient synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from the aldehydes, β-ketoesters and urea in ethanol using chlorosulfonic acid as the catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of excellent yields and short reaction time.
doi:10.1155/2005/237237 fatcat:vyxvmzatfnbplnswiwd6qlozgm