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Autonomous sensing the insulin peptide by an olfactory G protein coupled receptor modulates glucose metabolism
[article]
2020
bioRxiv
pre-print
Along with functionally intact insulin, diabetes-associated insulin peptides are secreted by β cells(1-3). By screening the expression and functional characterization of olfactory receptors in pancreatic islets, we identified Olfr109 as the receptor to detect insulin peptides. Engagement of one insulin peptide, insB:9-23, with Olfr109 diminished insulin secretion through Gi-cAMP signalling and promoted macrophage proliferation. Remarkably, Olfr109 deficiency alleviated intra-islet inflammatory
doi:10.1101/2020.12.18.423228
fatcat:vxbyav4bsrbfdcneaufgl273dm