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A single gene locus can produce multiple isoforms with divergent structural and functional properties in a process termed alternative splicing. Differential alternative splicing is implicated mechanistically in development, cell differentiation and disease. In some disease-driving genes, a slight shift (by as few as several percent) in the relative splice isoform proportions can trigger disease pathogenesis. RNA-Seq has become a popular and effective approach to quantify splicing events. Withfatcat:dbttl6sfr5fipjwn6ldzvu7she