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BMC Medical Genomics
With the development of high-throughput genotyping and sequencing technology, there are growing evidences of association with genetic variants and complex traits. In spite of thousands of genetic variants discovered, such genetic markers have been shown to explain only a very small proportion of the underlying genetic variance of complex traits. Gene-gene interaction (GGI) analysis is expected to unveil a large portion of unexplained heritability of complex traits. Methods: In this work, wedoi:10.1186/1755-8794-7-s1-s6 pmid:25077411 pmcid:PMC4101351 fatcat:swo2rmblp5fxhk7g2dieewebi4