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Nihon Kessho Gakkaishi
Crystal Structure of the Cohesin Loader Scc2 The ring-shaped cohesin complex entraps chromosomes and regulates chromosome biology. The cohesin core consists of Smc1, Smc3, Scc1 and Scc3. Scc2-Scc4 complex is known as a cohesin loader and loads cohesin onto chromosomes. Mutations of Scc2 cause human developmental diseases termed cohesinopathy. Here we determined the crystal structure of Chaetomium thermophilum Ct Scc2 and its interaction with cohesin. The structure consists mostly of HEATdoi:10.5940/jcrsj.59.121 fatcat:jixr2fd3hrg6nifwvv4lksblru