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Inhibitory control of synaptic signals preceding motor action in mouse frontal cortex
Preparatory activity in the frontal cortex preceding movement onset is thought to represent a neuronal signature of motor planning. However, how excitatory and inhibitory synaptic inputs to frontal neurons are integrated during movement preparation remains unclear. Here we address this question by performing in vivo whole-cell patch-clamp recordings in the secondary motor cortex (MOs) of head-fixed mice moving on a treadmill. We find that both superficial and deep principal neurons show slowlydoi:10.1101/2021.07.05.451151 fatcat:jysu5eagnne3zmjjuseoxwiicm