Cognitive Control Network Function in Alcohol Use Disorder Before and During Treatment With Lorazepam

Claire E. Wilcox, Andrew R. Mayer, Michael P Bogenschutz, Josef Ling, Charlene Dekonenko, Heather Cumbo
2014 Substance Use & Misuse  
Individuals with alcohol use disorders (AUDs) have deficits in cognitive control, but how they change with treatment is unclear. Seven patients with AUD and anxiety from an open-label trial of disulfiram plus lorazepam performed a multisensory Stroop task during fMRI (both pre and post initiation of treatment), and were compared to nine healthy controls (HCs) (n = 16; Albuquerque, NM; years 2009-2012). Evoked BOLD signal and resting state functional connectivity were compared (HC vs. AUD; Scan
more » ... vs. Scan 2). AUD demonstrated hyperactivity and altered connectivity in the cognitive control network compared to HC, but treatment did not normalize function.
doi:10.3109/10826084.2014.957771 pmid:25290463 pmcid:PMC4418428 fatcat:rryrzvapcjbt7hk4barceikw4y