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Redundant functions of B-Myb and c-Myb in differentiating myeloid cells
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
We show in this report that the human myeloid leukemia cell line GFD8 is a useful model to compare the biological function of the structurally related c-Myb and B-Myb proto-oncogenes and to investigate the c-myb domains required for this function. GFD8 cells are dependent for growth on granulocyte-macrophage colony-stimulating factor and differentiate in response to phorbol myristate acetate (PMA). We have stably transfected this cell line with constructs constitutively expressing c-Myb orpmid:9419419 fatcat:tq5osldqnzcx5cvf3mvbbjhwdq