White Matter Damage Disorganizes Brain Functional Networks in Amnestic Mild Cognitive Impairment

José Angel Pineda-Pardo, Pilar Garcés, María Eugenia López, Sara Aurtenetxe, Pablo Cuesta, Alberto Marcos, Pedro Montejo, Miguel Yus, Juan Antonio Hernández-Tamames, Francisco del Pozo, James T. Becker, Fernando Maestú
2014 Brain Connectivity  
Although progressive functional brain network disruption has been one of the hallmarks of Alzheimer's Disease, little is known about the origin of this functional impairment that underlies cognitive symptoms. We investigated how the loss of white matter (WM) integrity disrupts the organization of the functional networks at different frequency bands. The analyses were performed in a sample of healthy elders and mild cognitive impairment (MCI) subjects. Spontaneous brain magnetic activity
more » ... d with magnetoencephalography) was characterized with phase synchronization analysis, and graph theory was applied to the functional networks. We identified WM areas (using diffusion weighted magnetic resonance imaging) that showed a statistical dependence between the fractional anisotropy and the graph metrics. These regions are part of an episodic memory network and were also related to cognitive functions. Our data support the hypothesis that disruption of the anatomical networks influences the organization at the functional level resulting in the prodromal dementia syndrome of MCI.
doi:10.1089/brain.2013.0208 pmid:24617580 pmcid:PMC4064724 fatcat:sneufiec5re6hfrpgmr3plgvmm