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The Effects of Nuclear Factor-κB Decoy Oligodeoxynucleotide on Lipopolysaccharide-Induced Direct Acute Lung Injury
2009
Tuberculosis and Respiratory Diseases
Preserved Fulltext
Original Article JH Kim et al: NF-κB decoy ODN in LPS-induced ALI 96 Results: NF-κB decoy ODN treatment significantly decreased NF-κB activity in lung tissues. However, it failed to improve the parameters of LPS-induced direct ALI, including the concentrations of tumor necrosis factor-α and interleukin-6 in BALF, myeloperoxidase activity in BALF and histopathologic changes measured by the ALI score. Conclusion: NF-κB decoy ODN, which has been proven to be effective in indirect models, had no effect in the direct ALI model.
doi:10.4046/trd.2009.67.2.95
fatcat:rurithwadfeutk45knxuynlq5u