Identification and transfer of spatial transcriptomics signatures for cancer diagnosis

Niyaz Yoosuf, José Fernández Navarro, Fredrik Salmén, Patrik L. Ståhl, Carsten O. Daub
2020 Breast Cancer Research  
Distinguishing ductal carcinoma in situ (DCIS) from invasive ductal carcinoma (IDC) regions in clinical biopsies constitutes a diagnostic challenge. Spatial transcriptomics (ST) is an in situ capturing method, which allows quantification and visualization of transcriptomes in individual tissue sections. In the past, studies have shown that breast cancer samples can be used to study their transcriptomes with spatial resolution in individual tissue sections. Previously, supervised machine
more » ... methods were used in clinical studies to predict the clinical outcomes for cancer types.
doi:10.1186/s13058-019-1242-9 pmid:31931856 pmcid:PMC6958738 fatcat:pe3bysiqf5f37pjcaleosnlbue