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We examine the effective force between two nanometer scale solutes in water by Molecular Dynamics simulations. Macroscopic considerations predict a strong reduction of the hydrophobic attraction between solutes when the latter are charged. This is confirmed by the simulations which point to a surprising constancy of the effective force between oppositely charged solutes at contact, while like charged solutes lead to significantly different behavior between positive and negative pairs. Thedoi:10.1063/1.1632902 fatcat:ujmyspgphreo3iaujw7dxzf5o4