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The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection
[article]
2022
bioRxiv
pre-print
It is well-established that chronic HIV infection causes persistent low-grade inflammation that induces premature aging of the immune system in HIV patient including senescence of memory and effector CD8 T cells. To uncover the reasons of gradually diminished potency of CD8 T cells from chronically HIV infected people, we have analyzed cellular morphology and dynamics of the synaptic interface followed exposure of peripheral polyclonal CD8 T cells at various differentiation stages to planar
doi:10.1101/2022.01.13.476200
fatcat:f57mtdwfsvfuzhiihuqww7mpbi