The JNK-dependent CaMK pathway restrains the reversion of committed cells during osteoclast differentiation

E.-J. Chang, J. Ha, H. Huang, H. J. Kim, J. H. Woo, Y. Lee, Z. H. Lee, J. H. Kim, H.-H. Kim
2008 Journal of Cell Science  
and addition of active NFATc1 partially rescued the effect of JNK inhibition. In addition, the level of NFATc1 was decreased by knockdown of CaMK by RNAi and by catalytic inhibition of CaMK, which both caused the reversion of pOCs to macrophages. These data suggest that JNK activity is specifically required for maintaining the committed status during osteoclastogenesis and that the CaMK-NFATc1 pathway is the key element in that specific role of JNK. Supplementary material available online at
doi:10.1242/jcs.028217 pmid:18650497 fatcat:3u6ejsxpqjfqzdae66n5ft6dty