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Polyamine Metabolism as Chemotherapeutic Target in Protozoan Parasites
2002
Mini-Reviews in Medical Chemistry
Preserved Fulltext
Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono-and di-substituted polyamine analogs targeting polyamine interconversion, as well as more traditional targeting of synthetic enzymes
doi:10.2174/1389557023405549
pmid:12370040
fatcat:tfwywyfptraxvmeczvecghxnxe