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Biophysics of selectin–ligand interactions in inflammation and cancer
Selectins (L-, E-and P-selectin) are calcium-dependent transmembrane glycoproteins that are expressed on the surface of circulating leukocytes, activated platelets, and inflamed endothelial cells. Selectins bind predominantly to sialofucosylated glycoproteins and glycolipids (E-selectin only) present on the surface of apposing cells, and mediate transient adhesive interactions pertinent to inflammation and cancer metastasis. The rapid turnover of selectin-ligand bonds, due to their fast on-anddoi:10.1088/1478-3975/8/1/015013 pmid:21301059 fatcat:cvcel4a5jzg6jj3dvstagvepey