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DNA methylation marks inter-nucleosome linker regions throughout the human genome
Nucleosome organization and DNA methylation are two epigenetic mechanisms that are important for proper control of mammalian transcription. Numerous lines of evidence suggest an interaction between these two mechanisms, but the nature of this interaction in vivo remains elusive. Whole-genome DNA methylation sequencing studies have shown that human methylation levels are periodic at intervals of approximately 190 bp, suggesting a genome-wide relationship between the two marks. A recent reportdoi:10.7287/peerj.preprints.27v1 fatcat:ipmheiujkvfmhoea6kkuphu2da