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Using in silico predicted ancestral genomes to improve the efficiency of paleogenome reconstruction
2020
Ecology and Evolution
Paleogenomics is the nascent discipline concerned with sequencing and analysis of genome-scale information from historic, ancient, and even extinct samples. While once inconceivable due to the challenges of DNA damage, contamination, and the technical limitations of PCR-based Sanger sequencing, following the dawn of the second-generation sequencing revolution, it has rapidly become a reality. However, a significant challenge facing ancient DNA studies on extinct species is the lack of closely
doi:10.1002/ece3.6925
pmid:33304488
pmcid:PMC7713980
fatcat:pzssu7c5bzbrray6hp53cjy5o4