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Rapid oscillation of insulin release by the rat pancreatic islets under stringent Ca2+-free conditions
Journal of Endocrinology
Oscillation of insulin release by the pancreatic islets was evaluated under stringent Ca 2+ -free conditions for the first time. Isolated single rat islets were exposed to 16·7 mM glucose in the presence of 1·9 mM Ca 2+ , or under the stringent Ca 2+ -free conditions (Ca 2+ omission with 1 mM EGTA, 6 µM forskolin and 100 nM phorbol 12-myristate 13-acetate). Fifteen minutes after the initiation of glucose stimulation, effluent was collected at a 6-s interval, insulin was determined in duplicatedoi:10.1677/joe.0.1660545 pmid:10974649 fatcat:feo3qjmqyne47o46wvc2ru4t5e