A COMPARATIVE STUDY OF QUININE V/S ARTESUNATE IN SEVERE MALARIA PATIENTS IN NORTHWESTERN RAJASTHAN, INDIA

K Nayak, Rakesh Meena, Surendra Kumar, B Gupta, V Singh, Varun Kulkarni
2011 International Journal of Basic and Applied Medical Sciences   unpublished
Plasmodium falciparum (PF) and Plasmodium vivax (PV) are responsible for most of the global burden of malaria. With changing spectrum of clinical presentation in malaria, newer treatment regimens are evolving. So we plan to study comparative efficacy of quinine V/S artesunate in treatment of malaria. The study was conducted among 100 adult patients of severe malaria (Pf, Pv, Pf+Pv). The diagnosis of malaria was confirmed by demonstrating asexual form of parasites in peripheral blood smear and
more » ... l blood smear and positive rapid antigen test. Amongst study group, 65 were treated with artesunate (2.4 mg/kg over 10 minutes followed by 2.4 mg/kg every 24 hours) and 35 with Quinine (20mg/kg loading dose for 4 hrs in 500 ml D 10% and then 10mg/kg every 8 hrs). In both groups results were compared at PCT, FCT, CRT , side effects observed and hospitalization duration seen. Mean parasite clearance with artesunate 1.62 day while mean PCT with quinine 3.46 day, mean FCT with artesunate 2.17 day while quinine 3.5 day, CRT with artesunate 1.33 day while quinine 2.67 day, hypoglycemia, QTc prolongation, nausea, vomiting, tinnitus, vertigo was frequently seen side effects of quinine while no such side effect was seen with artesunate. We also found that to give artesunate as compare to quinine was easy. Out of 35 patients who were treated with quinine only one mortality occurred while no mortality with artesunate out of 65 patients. Artesunate is preferred drug over quinine to treat severe malaria patients.
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