Mapping the Human Cortical Surface by Combining Quantitative T1 with Retinotopy†

Martin I. Sereno, Antoine Lutti, Nikolaus Weiskopf, Frederic Dick
2012 Cerebral Cortex  
We combined quantitative relaxation rate (R 1 = 1/T 1 ) mapping-to measure local myelination-with fMRI-based retinotopy. Graywhite and pial surfaces were reconstructed and used to sample R 1 at different cortical depths. Like myelination, R 1 decreased from deeper to superficial layers. R 1 decreased passing from V1 and MT, to immediately surrounding areas, then to the angular gyrus. High R 1 was correlated across the cortex with convex local curvature so the data was first "de-curved". By
more » ... aying R 1 and retinotopic maps, we found that many visual area borders were associated with significant R 1 increases including V1, V3A, MT, V6, V6A, V8/ VO1, FST, and VIP. Surprisingly, retinotopic MT occupied only the posterior portion of an oval-shaped lateral occipital R 1 maximum. R 1 maps were reproducible within individuals and comparable between subjects without intensity normalization, enabling multicenter studies of development, aging, and disease progression, and structure/function mapping in other modalities.
doi:10.1093/cercor/bhs213 pmid:22826609 pmcid:PMC3729202 fatcat:hlhfbscd3nfxrmy4wcust4edc4