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Lowered insulin-sensitive Ca2+ transport in cultured glomerular mesangial cells from spontaneously hypertensive rats
The Japanese Journal of Nephrology
Insulin-resistant state has been postulated in the pathogenesis of hypertension. To investigate the role of insulin in Ca2+ regulation of the glomerular mesangial cell (MC) in hypertension, the effect of insulin on Ca2 transport and intracellular-free calcium concentration ([Ca2+],) was measured in serially passaged cultured MC obtained from spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). Insulin produced a substantial increase in 45Ca uptake as well as [Ca2+] ; in quiescentdoi:10.14842/jpnjnephrol1959.35.893 fatcat:5p7jcukj4bbcrjdrqnsfnxrgau