American Journal of the Medical Sciences
resistant to the acid-pepsin medium but both liberated free tannic acid in the alkaline-pancreatic medium. With the exception of the (single) specimen of Aeetannin, none of the products which were examined according to the methods described in this paper conformed strictly to the claims made for them. The Use of Arsphenamin in Non-syphilitic Diseases.-From a study of the literature, Reasonkr and Nichols (Jour. Am. Med. Assn., 1920, Ixxv, 645) conclude that for practical therapeutic pur¬ poses
... peutic pur¬ poses the beneficial effects of arsphenamin and neo-arsphenamin arc most apparent in a limited number of spirochetal diseases. They act as a specific in Vincent's angina, relapsing fever, yaws, gangosa and pulmonary spirochetosis (if given early) in man, and in equine influ¬ enza. A therapeutic effect is noted in rat-bite disease, in certain dental conditions and in fowl spirochetosis. Good results have been obtained in syphilitics with a number of non-syphilitic conditions which arc influenced adversely by that disease. Their use has been recommended in conditions in which arsenic is indicated; in such cases the effect is alterative rather than specific and there is no special advantage over liquor potnssii arsenitis. No apparent benefit has been found in such other spirochetal diseases as Weil's disease and yellow fever. There is a limited effect on certain protozoal diseases, such as malaria (tertian and quotidian), some of the trypanosomiases and leishmaniasis. This effect may he non-specific. With the excep¬ tion of anthrax and possibly glanders few favorable results are reported in bacterial diseases. Except in Vincent's angina, arsphenamin and nco-arsphcnainin should be administered intravenously in medium¬ sized dosage. Two or three injections usually ar.c sufficient, except in pulmonary spirochetosis which may require a series of injections. In diseases showing liver involvement, neo-arsphenamin has been recom¬ mended, as it is supposed to be less toxic than arsphenamin.