Glutathione S-Transferase Genotype Protects Against In Utero Tobacco Linked Lung Function Deficits

Louisa Owens, Ingrid A Laing, Jasminka Murdzoska, Guicheng Zhang, Steve W Turner, Peter N Le Souëf
2019 American Journal of Respiratory and Critical Care Medicine +61 2 93821477 Abbreviations FEF 25-75% -forced expiratory flow at 25-75% of forced vital capacity FEV1 -forced expiratory volume in 1 second FVCforced vital capacity GSTglutathione s-transferase ITSin utero tobacco smoke exposure PCRpolymerase chain reaction PIAF -Perth infant asthma follow-up study ITSin utero tobacco smoke V'maxFRCmaximum flow at functional residual capacity Conclusions GST genotypes may have protective effects against the deficits in lung
more » ... ficits in lung function associated with in utero tobacco exposure. This offers potential preventative targets in anti-oxidant pathways for at-risk infants of smoking mothers. Abstract Words: 247
doi:10.1164/rccm.201807-1332oc fatcat:yib4rprm25hfhexsyhefeyv46y