Analyzing Patterns of Microbial Evolution Using the Mauve Genome Alignment System [chapter]

Aaron E Darling, Todd J Treangen, Xavier Messeguer, Nicole T Perna
2007 Msphere  
During the course of evolution, genomes can undergo large-scale mutation events such as rearrangement and lateral transfer. Such mutations can result in significant variations in gene order and gene content among otherwise closely related organisms. The Mauve genome alignment system can successfully identify such rearrangement and lateral transfer events in comparisons of multiple microbial genomes even under high levels of recombination. This chapter outlines the main features of Mauve and
more » ... es of Mauve and provides examples that describe how to use Mauve to conduct a rigorous multiple genome comparison and study evolutionary patterns.
doi:10.1007/978-1-59745-515-2_10 pmid:18025691 fatcat:kkkohaxohva4xb2ms3zmlsoxlm