The comparison of teratogenic and carcinogenic effects of some carbamate compounds

J A DiPaolo, J Elis
1967 Cancer Research  
Ethyl carbamate and a series of related compounds were given in single intraperitoneal doses to pregnant Syrian hamsters on Day 8 of gestation, and fetuses were examined for malformations on Day 13 of gestation. Urethan produced a variety of malforma tions and growth retardation. Of the compounds modified in the carboethoxy end, n-propyl carbamate was as teratogenic as the ethyl carbamate, and /3-hydroxyethyl carbamate had only bor derline effect, while allyl carbamate and n-butyl carbamate
more » ... completely negative. Four compounds modified in the cabamyl portion of the molecule were tested. Three of these, ethyl Nmethylcarbamate, ethyl .V-hydroxycarbamate, and diethylcarbonate, were teratogenic; a fourth, ethyl A',Ar-dimethyIcarbamate was not teratogenic. The ethyl A*-hydroxycarbamate was the most potent teratogen tested. Although no qualitative differences were found among the various compounds tested, ethyl A'-hydroxycarbamate produced a quantitatively greater number of fetuses with malformed extremities and anophthalmia. The diethylcarbonate was as potent as urethan, the ethyl Nmethylcarbamate was more teratogenic than urethan, while the ethyl A',.V-dimethylcarbamate was negative. The similarity of abnormalities produced by these teratogens suggests a common mechanism of action for these compounds. Striking positive correlations were found between the terato genic effects in hamsters and skin tumor initiation and lung adenomas in mice.
pmid:6051281 fatcat:b52mxv76wfetvgbnprey547t6i