Preparation of the Diclofenac Sodium pH Sensitive Gel for Eyes

YAN DONG, MIAO MIAO MA, XIN LIANG, LI LI, TAO XU, FENG XU, WEI DONG
2017 DEStech Transactions on Engineering and Technology Research  
Objective: To prepare the diclofenac sodium pH sensitive gel for eyes (DS-pH sensitive gel). Methods: It's used for the index that viscosity under non-physiological conditions and physiological conditions were less than 1100mPa·s and more than 2500mPa·s respectively, the dosage ranges of Carbopol 980 and HPMC were screened. The formula of DS-pH sensitive gel was optimized by orthogonal test. Results: The best formula contained Carbopol 980 0.35g, HPMC 1.0g, ethylparaben 0.01 g, mannitol 5g,
more » ... ofenac sodium 100mg, and water for injection 100mL. Conclusion: The DS-pH sensitive gel was prepared successfully.
doi:10.12783/dtetr/mcee2017/15783 fatcat:vlv3pa7cyrhhlk7l774dbjxufy