Experimental Models for SARS-CoV-2 Infection

Taewoo Kim, Jeong Seok Lee, Young Seok Ju
2021 Molecules and Cells  
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is a novel virus that causes coronavirus disease 2019 (COVID-19). To understand the identity, functional characteristics and therapeutic targets of the virus and the diseases, appropriate infection models that recapitulate the in vivo pathophysiology of the viral infection are necessary. This article reviews the various infection models, including Vero cells, human cell lines, organoids, and animal models, and discusses their
more » ... s and disadvantages. This knowledge will be helpful for establishing an efficient system for defense against emerging infectious diseases.
doi:10.14348/molcells.2021.0094 pmid:34187969 pmcid:PMC8245318 fatcat:hucw6d4ovvetlmcf4gq3rg3xwe