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Pharmacodynamic Characterization of Nitric Oxide-Mediated Vasodilatory Activity in Isolated Perfused Rat Mesenteric Artery Bed
2011
Biological and Pharmaceutical Bulletin
Vasodilation profiles following a short-term infusion of nitric oxide (NO), acetylcholine (ACh), and sodium nitroprusside (SNP) into an isolated perfused mesenteric artery bed were analyzed in rats to examine their vasodilatory efficacy under physiological conditions. These compounds commonly increase the intracellular NO concentration to exert vasodilatory activity. In an experiment with exogenous NO infusion where 100 m ml of 1 : 300 diluted NO-saturated solution (approx. 53 pmol of NO) was
doi:10.1248/bpb.34.1487
pmid:21881238
fatcat:m4d3sedljnetbea5rdxdthgdgu