NR2F2 Plays a Major Role in Insulin-induced Epithelial-Mesenchymal Transition in Breast Cancer Cells [post]

2019 unpublished
The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclear receptor subfamily 2, group F member 2 (NR2F2) has been implicated in the development of breast cancer, however its contribution to insulin-induced EMT in breast cancer remains unclear.
more » ... remains unclear. Overexpression and knockdown of NR2F2 was used in two breast cancer cell lines, MCF-7 and MDA-MB-231 to investigate
doi:10.21203/rs.2.15281/v1 fatcat:4l3rezrl5vgtderngsw7mtajly