Ribavirin suppresses bacterial virulence by targeting LysR-type transcriptional regulators

Rahul Shubhra Mandal, Atri Ta, Ritam Sinha, Nagaraja Theeya, Anirban Ghosh, Mohsina Tasneem, Anirban Bhunia, Hemanta Koley, Santasabuj Das
2016 Scientific Reports  
Supplementary movie Dynamic interaction of ribavirin within AphB co-inducer/ligand binding site, as evident from 20ns molecular dynamic simulation. Supplementary figure S1. Ribavirin does not alter the expression of AphB of N16961 wt (a) and Hrg of S. Typhi Ty2 strains in vitro as shown by western blot: Bacterial strains, N16961 (a) and S. Typhi Ty2 (c) were cultured in AKI media or LB at 37°C with shaking in the presence of increasing concentrations of ribavirin.
doi:10.1038/srep39454 pmid:27991578 pmcid:PMC5171790 fatcat:xuhx3v7mlzbx5l3pimcurycw6m