Association of specific language impairment candidate genes CMIP and ATP2C2 with developmental dyslexia in Chinese population

Guoqing Wang, Yuxi Zhou, Yong Gao, Huan Chen, Jiguang Xia, Junquan Xu, Michael S.Y. Huen, Wai Ting Siok, Yuyang Jiang, Li Hai Tan, Yimin Sun
2015 Journal of Neurolinguistics  
Developmental dyslexia (DD) and specific language impairment (SLI) are distinct language disorders. Their phenotypic overlap and co-morbidity are frequently reported. In addition, numerous evidences indicate that genetic factors play an important role in DD and SLI. Therefore, it is worthwhile to identify possible genetic linkage shared by these two disorders. Here, we selected 178 Tag SNPs from two SLI candidate genes (CMIP and ATP2C2) and performed high density genotyping in a large unrelated
more » ... n a large unrelated Chinese DD cohort with 502 dyslexic cases and 522 healthy controls. Although some SNPs showed significant association (P min ¼ 0.0016) with DD
doi:10.1016/j.jneuroling.2014.06.005 fatcat:4brcywezn5b57jfoecxxrybwjq