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Frequency gradients in heterogeneous oscillatory media can spatially localize self-organized wave sources that coordinate system-wide activity
[article]
2019
arXiv
pre-print
Rhythmogenesis, which is critical for many biological functions, involves a transition to coherent activity through cell-cell communication. In the absence of centralized coordination by specialized cells (pacemakers), competing oscillating clusters impede this global synchrony. We show that spatial symmetry-breaking through a frequency gradient results in the emergence of localized wave sources driving system-wide activity. Such gradients, arising through heterogeneous inter-cellular coupling,
arXiv:1912.07271v1
fatcat:ojwzirrtrjblfgonlchxhvsnc4