Effects of Glucosamine on Insulin and Glucagon Secretion in Dogs and Ducks

HIROSHI KAJINUMA, TAKESHI KUZUYA, TAKEHIKO IDE, JEAN M. TYLER
1975 Endocrinologia Japonica  
Synopsis The effects of infusion of glucosamine on immunoreactive glucagon (IRG) and insulin (IRI) secretion were studied in dogs and ducks. During systemic infusion of glucosamine, hyperglycemia developed and insulin secretion was inhibited in both species. An immediate and sustained elevation of peripheral IRG levels was induced in ducks but a transient rise, detectable only in the pancreatic vein blood, was provoked in dogs. Suppression of insulin release and stimulation of glucagon release
more » ... f glucagon release may be mediated by the inhibition of glucose utilization in and a-cells. The very prompt response of IRG in ducks may imply that glucosamine has a specific stimulating effect on the a-cells of ducks. Intrapancreatic administration of glucosamine in dogs, however, failed to elicit the rise of IRG, although insulin secretion was inhibited. Thus, it is suggested that the systemic administration of glucosamine in dogs may stimulate IRG secretion by some indirect effect.
doi:10.1507/endocrj1954.22.517 pmid:1231993 fatcat:gmnmjb3nxnaexmwcyg53bvtuem