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ENCoM is a coarse-grained normal mode analysis method recently introduced that unlike previous such methods is unique in that it accounts for the nature of amino acids. The inclusion of this layer of information was shown to improve conformational space sampling and apply for the first time a coarse-grained normal mode analysis method to predict the effect of single point mutations on protein dynamics and thermostability resulting from vibrational entropy changes. Here we present a web serverdoi:10.1093/nar/gkv343 pmid:25883149 pmcid:PMC4489264 fatcat:ftzz676gi5celojsthlly2sbpy