Formation of drug nanocrystals under nanoconfinement afforded by liposomes

D. Cipolla, H. Wu, S. Salentinig, B. Boyd, T. Rades, D. Vanhecke, A. Petri-Fink, B. Rothin-Rutishauser, S. Eastman, T. Redelmeier, I. Gonda, H. K. Chan
2016 RSC Advances  
In response to freeze–thaw, liposome-encapsulated antibiotic (A) is converted into nanocrystalline form (B) resulting in an attenuated drug release profile.
doi:10.1039/c5ra25898g fatcat:vl77qs4lxvdhrdl6y3n7eaqkia