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Formation and selection of intergenogroup reassortants during cell culture adaptation of rotaviruses from dually infected subjects

R L Ward, O Nakagomi, D R Knowlton, M M McNeal, T Nakagomi, N Huda, J D Clemens, D A Sack
1991 Journal of Virology  

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A previous study showed that intergenogroup reassortants of human rotaviruses can persist in nature (R. L. Ward, 0. Nakagomi, D. R. Knowlton, M. M. McNeal, T. Nakagomi, J. D. Clemens, D. A. Sack, and G. M. Schiff, J. Virol. 64:3219 -3225, 1990), but the mechanisms involved in their formation and selection had not been determined. In this study it was shown that, during cell culture adaptation of rotaviruses belonging to different genogroups from stools of dually infected subjects,
more » ... reassortants were formed and selected, presumably mimicking the processes that occur in nature. ing to different genogroups.
doi:10.1128/jvi.65.5.2699-2701.1991 fatcat:eb7nibghirckhivfpnj6r2ydn4
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R L Ward, O Nakagomi, D R Knowlton, M M McNeal, T Nakagomi, N Huda, J D Clemens, D A Sack. "Formation and selection of intergenogroup reassortants during cell culture adaptation of rotaviruses from dually infected subjects." Journal of Virology 65.5 (1991) 2699-2701