Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer

Alex Thompson, Hugh Manning, Mikkel Brydegaard, Sergio Coda, Gordon Kennedy, Rakesh Patalay, Ulrika Waitong-Braemming, Pieter De Beule, Mark Neil, Stefan Andersson-Engels, Yoshifumi Itoh, Niels Bendsøe (+4 others)
2011 Optical Biopsy IX  
We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a statistically significant decrease in the autofluorescence lifetime of basal cell carcinomas
more » ... to neighbouring healthy tissue. A study of autofluorescence signals associated with the onset of osteoarthritis indicates autofluorescence lifetime changes associated with collagen degradation.
doi:10.1117/12.875120 fatcat:gzzmn2o7bjdxvlowa3cl3whrsq