OP0240 Favourable longterm outcome in patients with giant cell arteritis treated with tocilizumab. real life data from a swiss centre

A. Rubbert-Roth, T. Neumann, P. Rein, H. Prillwitz, J. von Kempis
2018 FRIDAY, 15 JUNE 2018   unpublished
Methods: Cohort study of IgAV patients (ICD-9-CM 287.0/ICD-10-AM D69.0) using non-exposed age-matched controls (1:3), where pregnancy-related events and outcomes (see table 1 for ICD codes) were extracted from state-wide hospital morbidity data for period 1980 to 2015. Results are presented as odds ratios (95% CI) versus controls. Results: Pregnancy-related contacts (n=1,440) occurred in 49.5% of all female IgAV patients (n=347) and in 37% of all female controls (n=914). IgAV patients were
more » ... patients were younger at first pregnancy (23.7 vs 26.4 years, p<0.01) and had a higher overall mean number of hospital pregnancy contacts than controls (5.4 vs 3.1, p<0.001). IgAV patients experienced 168 uncomplicated live births, 93 complicated (including preterm) deliveries and 32 abortive pregnancies. The risk for abortion (OR 1.3, CI: 0.7 to 2.3), complicated delivery (OR 0.9, CI: 0.7 to 1.3) or classification as high-risk pregnancy (OR 0.94, CI: 0.74 to 1.24) was similar for IgAV patients compared to controls, despite a higher risk of hypertensive disorders (OR 4.4 CI2.1-9.1). Abstract OP0239 - Table 1 . Diagnostic codes used for data extraction from health registries
doi:10.1136/annrheumdis-2018-eular.6585 fatcat:zeyrczudojcijinwz6a3jderia