Internet Archive Scholar

Chemical profiling of alkylamides from the "herbal Botox", Acmella oleracea, cultivated in Mizoram and their pharmacological potentials

P.B. Lalthanpuii, Department of Life Sciences, Pachhunga University College, Aizawl-796 001, India, Z.T. Laldinpuii, S. Lalhmangaihzuala, K. Vanlaldinpuia, B. Lalruatfela, C. Lalnunfela, Laldinchhana, R. Lalawmpuii, T.C. Lalhriatpuii, H. Lalhlenmawia, K. Lalchhandama (+10 others)
2020 Journal of environmental biology  

Preserved Fulltext

Web Archive Capture PDF (1.3 MB)
https://web.archive.org/web/20200901155052/http://www.jeb.co.in/journal_issues/202007_jul20_spl/paper_06.pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL. The file type is application/pdf.

Aim: Methodology: Results: Interpretation: Keywords: To perform chemical analysis and study the antibacterial and antiparasitic activities of Acmella oleracea extracts. The methanol, chloroform, and hexane extracts of A. oleracea were prepared and analysed by GC-MS and HPLC. An active ethyl acetate fraction obtained from methanol extract was tested on Gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and a Gram-positive species Bacillus subtilis. An
more » ... ntestinal tapeworm, Raillietina echinobothrida was used for anthelmintic study and the effects were examined by scanning electron microscopy. GC-MS revealed that N-isobutyl-(2E, 4Z, 8Z, 10E)dodecatetraenamide was the dominant compound in all the three extracts. N-(2-Methylbutyl)dodeca-2,4-diene-8,10diynamide, N-(2-phenylethyl) non-2(E)-en-6, 8-diynamide and (2E,4E,10E)-N-isobutylhexadeca-2,4,10-trienamide were also detected. (2E,6Z,8E)-N-Isobutyl-2,6,8decatrienamide was confirmed by HPLC in all extracts. The methanol-ethyl acetate extract was effective against all the four bacteria with maximum activity against Bacillus subtilis. Anthelmintic effects on R. echinobothrida included tegumental shrinkage, surface erosion, obliteration of the spines, and formation of pits on the body segments. A. oleracea is shown to be rich in alkylamides. As the dominant compounds, these alkylamides can be attributed to the antibacterial and anthelmintic properties of the medicinal plant.
doi:10.22438/jeb/4(si)/ms_1910 fatcat:qwmyvvm6hba3zibn2dji64jjty
Open Access
Citation

P.B. Lalthanpuii, Department of Life Sciences, Pachhunga University College, Aizawl-796 001, India, Z.T. Laldinpuii, S. Lalhmangaihzuala, K. Vanlaldinpuia, B. Lalruatfela, C. Lalnunfela, Laldinchhana, R. Lalawmpuii, T.C. Lalhriatpuii, H. Lalhlenmawia, K. Lalchhandama, Department of Chemistry, Pachhunga University College, Aizawl-796 001, India, Department of Chemistry, Pachhunga University College, Aizawl-796 001, India, Department of Chemistry, Pachhunga University College, Aizawl-796 001, India, Department of Life Sciences, Pachhunga University College, Aizawl-796 001, India, Department of Life Sciences, Pachhunga University College, Aizawl-796 001, India, Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Zemabawk-796 017, India, Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Zemabawk-796 017, India, Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Zemabawk-796 017, India, Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Zemabawk-796 017, India, Department of Life Sciences, Pachhunga University College, Aizawl-796 001, India. "Chemical profiling of alkylamides from the "herbal Botox", Acmella oleracea, cultivated in Mizoram and their pharmacological potentials." Journal of environmental biology 41.4(SI) (2020) 845-850