Gastric ulcer is one of the most common gastrointestinal tract diseases, and has affected on humans for centuries. Helicobacter pylori infection, use of drugs such as Nonsteroidal anti-inflammatory drugs (NSAIDs), and stress are some of the known factors that can cause gastric ulcers. NS (Nigella sativa) has been used in traditional medicine. It used for the treatment of a variety of diseases including gastrointestinal disorders. The aim of this study to evaluate the balanced between defensive

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... nd aggressive factors in the stomach and investigated the treated effects of NS ethanolic extract against Indomethacin induced gastric ulcer in rats. 48 Rats were divided at random into 6 groups 8 for each, 1 st G negative control group treated with CMC 0.5 ml /kg BWt, 2 nd NSG treated with NS 150mg/kg BWt, 3 rd OG treated with Omebrazole 3 mg/ kg BWt, 4 th IG Indomethacin group treated with 30mg / kg BWt, 5 th INSG Indomethacin and NS, and 6 th IOG Indomethacin and Omebrazole with the same dose. These studies revealed the successful effectiveness of the alcoholic extract of Nsativa seeds in doses of 150 mg/kg daily for two weeks in inducing significant (P< 0.05) treatment against gastric ulcer compared with IG. INSG and IOG showed a significant increase of RBCs x10 6 /mm 3 , Neutrophils %, Prostaglandin E 2 (PGE 2 ng/l), NO 3 µmol/ml and Reduced Glutathione GSH. and significant decrease of WBCs, HB, Lymphocytes %, PH, Total Acidity, Free Acidity , NO 2 and MDA. Our results suggest that NS extract possesses significant antiulcerogenic actions in gastric ulcer induced by using indomethacin (as NSAIDs) that might be related to its anti-inflammatory and antioxidant activity.