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The glymphatic system (GS) hypothesis states that advective driven cerebrospinal fluid (CSF) influx from the perivascular spaces into the interstitial fluid space rapidly transport solutes and clear waste from brain. However, the presence of advection in neuropil is contested and solutes are claimed to be transported by diffusion only. To address this controversy, we implemented a regularized version of the optimal mass transport (rOMT) problem, wherein the advection/diffusion equation is thedoi:10.1038/s41598-020-59045-9 pmid:32029859 pmcid:PMC7004986 fatcat:uxarxicocvhq7bx7f27qoocn3u