Vasopressin modulates hypothalamo-pituitary activity by paracrine action during acute and chronic immobilization stress in rats

Iva Lakic, P. Vujovic, N. Jasnic, S. Djurasevic, Gordana Cvijic
2011 Archives of Biological Sciences  
The aim of the study was to examine changes in corticotropin releasing hormone (CRH), vasopressin (VP), adrenocorticotropin (ACTH) as well as VP3 receptor protein concentration in the hypothalamus and the pituitary of rats exposed to acute (3 h) and chronically repeated (3 h daily for 7 days) immobilization stress. Our results show that, unlike the increase in ACTH, there were no changes in serum VP despite the significant changes in this hormone and its receptor concentrations in the
more » ... ns in the hypothalamus and pituitary (HP). This suggests that VP regulates HP activity by predominantly acting in a paracrine manner under the examined stress condition.
doi:10.2298/abs1103579l fatcat:4letltk5rrgv7kpscyrqe6c3ii