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The liver is the largest solid organ in the body and is critical for metabolic and immune functions. However, little is known about the cells that make up the human liver and its immune microenvironment. Here we report a map of the cellular landscape of the human liver using single-cell RNA sequencing. We provide the transcriptional profiles of 8444 parenchymal and non-parenchymal cells obtained from the fractionation of fresh hepatic tissue from five human livers. Using gene expressiondoi:10.1038/s41467-018-06318-7 pmid:30348985 pmcid:PMC6197289 fatcat:372vka7y2bbg7n46s4druiw6ta