The present study aims to investigate the influence of feeding dietary sesame and flaxseeds on immunity in sixty male experimental ratsof Sprague Dawleystrain.Their weight ranged between(120 to 125 g).They were divided as follow:The first group as a negative control group which fed on basal diet. The other five groups wereimmune suppressed by theadministration ofAflatoxinB1 and fed on basal diet. Group two was a positive immune control group and fed on basal diet. Groups three and four fed on

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... sal diet with (5,10 %) sesame seeds powder. While groups five and six fed on basal diet with (5,10%) of flaxseedspowder for four weeks.Measurement of body weight, performed serum samples were collected to determine lipid peroxide, nitric oxide and immunoglobulin G(antibodies level). The results showed that immunesuppression group (2) resulted in a slight decrease in mean body weight as compared to the control negative group (1). Rats treated with 10% sesame seeds showed the greatest increase in weight. The lipid peroxide and nitric oxide levels were found to be increased in immunesuppressed rats group (2) as compared to the control group (1). Treatment of rats fed on sesame and flaxseeds resulted in decreasing these levels especially in 10% sesame group. The immunoglobulin G was decreased in immunesuppressed rats group (2) as compared to control group (1). Rats fed on sesame andflaxseeds showed an increase, especially in 10% sesame fed group of rats. Therefore, it is recommended to be used dietary sesame or dietary flaxseeds for improving immunity.